There are two sets of coefficients taken into account when computing the actual parameters from the baseline ones.
One consists of a coefficient which has one value for every cell and every external or internal factor, and which tells how much is the factor relevant to the cell. For example, it may tell that the cell is vagally inervated, or that the cell is placed in a region in which oxygenation changes. This coefficient is called coefficient of relevance of the factor for the cell.
For every factor and for every cell category, there is a transfer function, which tells how does each factor influence every
parameter of cells in that category. The functions used for
this purpose are from a class named limited linear transfer
functions. There are four function
arguments, named
,
.
When the value of the factor is less than
then the
value of the function is
. When the value of the
factor is more than
then the value of the function
is
. When the value of the factor is
between
and
the value of the function
varies linearly between
and
.
For every cell, the factors are applied as follows: every factor
is multiplied by the relevance coefficient for the
cell. Then, the
value for the result of
applying the relevance coefficient to the factor is computed
for every parameter in the cell. Then, for every parameter,
the product of these
values is computed and the
result is multiplied with the basic value of the parameter,
thus resulting the value of the actual parameter. This
is repeated at the initiation of every cycle for every cell.
The baseline value of a factor with respect
to a cell is the value for which the
of the factor for the
cell is 1.0.
PROBLEM. Wouldn't it be more normal for the relevance coefficient to amplify/diminish the difference between the 1 and the value of? In this case a relevance coefficient of 0.0 would make
1.0 and make the factor irrelevant. A gradient towards the maximum intended effect of the factor would be obtained by varying the relevance coefficient between 0.0 and 1.0.